反应详情

Into a 25 mL round bottom flask were added 2,2-dimethyl-1-(5-(1-(4-(methylthio)benzyl)piperidin-3-ylamino)-1H-indazol-1-yl)propan-1-one (250 mg, 0.6 mmol), methanol (5 mL), and sodium methoxide (93 mg, 1.7 mmol). The reaction was stirred at room temperature until the starting material was consumed as monitored by HPLC. The mixture was diluted with ethyl acetate (10 mL), washed with water (2×10 mL), and the organic phase was separated, dried over MgSO4, filtered and evaporated to dryness to afford the title compound (180 mg, 89%).

1. customwas consumed
2. additionThe mixture was diluted with ethyl acetate (10 mL)
3. washwashed with water (2×10 mL)
4. customthe organic phase was separated
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customevaporated to dryness