Water → tert-butyl 2-acetamido-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate

HRID 191209Notes

Reaction equation

HRID 191209 reaction equation
[CH3:18][C:19]([Cl:20])=[O:21].[NH2:1][c:2]1[s:3][c:4]2[c:9]([n:10]1)[CH2:8][CH2:7][N:6]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:5]2.[OH2:22].[cH:23]1[cH:24][cH:25][n:26][cH:27][cH:28]1>>[NH:1]([c:2]1[s:3][c:4]2[c:9]([n:10]1)[CH2:8][CH2:7][N:6]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:5]2)[C:19]([CH3:18])=[O:21]

Participants

5

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 6367Acetyl chlorideHCID 11357283tert-butyl 2-amino-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate

Product 1

HCID 47146196tert-butyl 2-acetamido-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate

Sources & evidence

ORD record
ord-96320f7376cc4a909e11a4089b5b6983
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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