HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1912194Generated: November 3, 2026
Water → 1-(2-(2-Methoxy-4-nitrophenoxy)ethyl)pyrrolidine
https://huagongshe.com/reaction/1912194
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-(2-Chloroethyl)pyrrolidine hydrochloride | HCID 81668 | — |
| Reactant | Potassium 2-methoxy-4-nitrophenolate | HCID 14144719 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2-(2-Methoxy-4-nitrophenoxy)ethyl)pyrrolidine | HCID 17989355 | — |
Reaction Steps
A suspension of potassium 2-methoxy-4-nitro-phenolate (2.0 g, 9.7 mmol), 1-(2-chloro-ethyl)-pyrrolidine hydrochloride (2.0 g, 12 mmol) and cesium carbonate (7.0, 22 mmol) in DMF (35 mL) was heated at 80° C. for 16 h. The mixture was allowed to cool to room temperature, poured into water (60 mL) and extracted with EtOAc (2×50 mL). The combined extracts were washed with brine, dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated and used in the next step without purification. MS (ES+): m/z 267 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08604042B2 |
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| Source dataset | uspto-grants-2013_12 |
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| ORD ID | ord-33cd9a459c2e435485ffb79b409b9b6a |
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| Source note | uspto-grants-2013_12 |
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