HRID1912231

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21

HCID6957986

N-{[(9H-Fluoren-9-yl)methoxy](hydroxy)methylidene}tyrosine

C24H21NO5

结构：CC(C)[C@H](N)C(=O)O.CC(N)N.CCC(=O)C1=CC(=O)NC1=O.NC(=O)C[C@H](N)C(=O)O

HCID131731084

未命名化合物

PRODUCTS

生成物

结构：CC(C)[C@H](N)C(=O)O.CC(N)N.CCC(=O)C1=CC(=O)NC1=O.N[C@@H](Cc1ccc(O)cc1)C(=O)O

HCID131731083

未命名化合物

PROCEDURE

实验过程

AF-Tyrosine-Valine-diaminoethane-propionyl-maleimide (5d) was prepared in the same manner as 5c, using Fmoc-Tyr for AA1. Yield: 36 mg (68%) of white solid. RP-HPLC analysis: >95% at 7.8 min; ESMS m/z=1201.67 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f08853bc42d44319ad12d365d6998f20
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08609105B2
来源说明: uspto-grants-2013_12

反应 SMILES

N[C@H](C(O)=O)CC(=O)N.[NH2:10][C@H:11]([C:15]([OH:17])=[O:16])[CH:12]([CH3:14])[CH3:13].[NH2:18][CH:19]([NH2:21])[CH3:20].[C:22]([C:26]1[C:27]([NH:29][C:30](=[O:32])[CH:31]=1)=[O:28])(=[O:25])[CH2:23][CH3:24].[NH:33](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:34]([C:43]([OH:45])=[O:44])[CH2:35][C:36]1[CH:41]=[CH:40][C:39]([OH:42])=[CH:38][CH:37]=1>>[NH2:33][C@H:34]([C:43]([OH:45])=[O:44])[CH2:35][C:36]1[CH:37]=[CH:38][C:39]([OH:42])=[CH:40][CH:41]=1.[NH2:10][C@H:11]([C:15]([OH:17])=[O:16])[CH:12]([CH3:14])[CH3:13].[NH2:18][CH:19]([NH2:21])[CH3:20].[C:22]([C:26]1[C:27]([NH:29][C:30](=[O:32])[CH:31]=1)=[O:28])(=[O:25])[CH2:23][CH3:24]