Water → Strontium

HRID 1912313Notes

Reaction equation

HRID 1912313 reaction equation
[C:1]([O-:7])(=[O:6])[CH2:2][C:3]([O-:5])=[O:4].[Ca+2].O.[Sr:10]>>[C:1]([O-:7])(=[O:6])[CH2:2][C:3]([O-:5])=[O:4].[Sr+2:10].[Sr:10]

Participants

5

Reactant 3

HCID 962Water2×HCID 51711419455-76-6HCID 5359327Strontium2×

Product 2

HCID 5359327StrontiumHCID 10313457Strontium malonate

Procedure

The compounds (active strontium test-article: Sr-malonate, 189.6 g/mol; Placebo substance, calcium malonate, 142.1 g/mol) was suspended in drinking water for the rats. The salts were prepared in a solution of 1.6 g/l, which is close to saturation (22-25° C.). Thus extensive stirring was required to completely dissolve the substances. A new batch of drinking water was prepared fresh every week for the duration of the experiment. When not in use the solution was stored at room temperature in a closed container. Preliminary experiments showed that the animals each drink between 60 and 90 ml/24 h resulting in approximate strontium dosing of 120 mg strontium malonate/day equal to 55.4 mg of ionic strontium.

Workup

  1. customThe salts were prepared in a solution of 1.6 g/l, which
  2. customis close to saturation (22-25° C.)
  3. dissolutionto completely dissolve the substances
  4. customwas stored at room temperature in a closed container
  5. customeach drink between 60 and 90 ml/24 h

Sources & evidence

ORD record
ord-7813d2de6dda428a81368bac0ce06d6b
Source dataset
uspto-grants-2013_12
Patent number
US08609616B2

Reaction notes

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