4-[(10-benzyl-9,10-diazatricyclo-[4.2.1.12,5]dec-9-yl)-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide → 4-[(2,7-diazatricyclo[4.4.0.03,8]dec-2-yl)-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide

Participants

Reaction Steps

The same procedure of Example 5.1 was repeated, but using instead of the compound prepared in Example 4.1 the compound 4-[(7-benzyl-2,7-diazatricyclo[4.4.0.03,8]dec-2-yl)-(3-methoxy-phenyl)methyl]-N,N-diethyl benzamide of Example 4.5. The compound 4-[(2,7-diazatricyclo[4.4.0.03,8]dec-2-yl)-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide was obtained. Yield: 90%. IR (nujol) (λ=cm−1) 1670 (C═O), 3100 (NH); 1H-NMR (CDCl3) δ 1.00-1.40 (m, 6H); 1.90-2.50 (m, 10H); 2.90-3.00 (m, 2H); 3.10-3.30 (m, 2H); 3.40-3.60 (m, 2H); 3.96 (s, 3H); 4.95 (s, 1H); 6.65-6.85 (m, 1H); 7.00-7.40 (m, 5H); 7.48 (d, 2H, J=6.0 Hz). Anal. calc. for C27H35N3O2: C, 74.79; H, 8.14; N, 9.69. Found: C, 74.81; H, 8.11; N, 9.68.

Provenance & Evidence