4-[(10-benzyl-9,10-diazatricyclo-[4.2.1.12,5]dec-9-yl)-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide → HCID 67238602, compound

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Reaction Steps

The procedure of Example 5.1 was repeated, but using in place of the compound prepared in Example 4.1 the compound {4-[(7-benzyl-2,7-diazatricyclo[4.4.0.03,8]dec-2-yl)-(3-methoxyphenyl)methyl]phenyl}-pyrrolidin-1-yl-methanone of Example 4.8. The compound {4-[(2,7-diazatricyclo[4.4.0.03,8]dec-2-yl)-(3-methoxyphenyl)methyl]phenyl}-pyrrolidin-1-yl-methanone was obtained. Yield: 90%; IR (nujol) (λ=cm−1) 1680 (C═O), 3100 (NH); 1H-NMR (CDCl3) δ 1.10-2.20 (m, 11H); 2.25-2.35 (m, 2H); 2.95-3.05 (m, 2H); 3.30-3.40 (m, 3H); 3.55-3.75 (m, 3H); 3.78 (s, 3H); 4.96 (s, 1H); 7.00-7.09 (m, 2H); 7.15-7.30 (m, 2H); 7.40-7.55 (m, 4H). Anal. calc. for C27H33N3O2: C, 75.14; H, 7.71; N, 9.74. Found: C, 74.98; H, 7.69; N, 93.73.

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