(S,E)-tert-butyl 4-(4-(methylsulfonyl)-2-aminobut-3-en-1-yl)benzylcarbamate → (S,E)-tert-butyl (5-amino-7-(methylsulfonyl)hept-6-en-1-yl)carbamate

HRID 1912369Notes

Reaction equation

HRID 1912369 reaction equation
C([NH:20][C@H:21](/[CH:34]=[CH:35]/[S:36]([CH3:39])(=[O:38])=[O:37])[CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30])(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.CS(/C=C/[C@@H](N)CC1C=CC(CNC(=O)OC(C)(C)C)=CC=1)(=O)=O>>[NH2:20][C@H:21](/[CH:34]=[CH:35]/[S:36]([CH3:39])(=[O:38])=[O:37])[CH2:22][CH2:23][CH2:24][CH2:25][NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30]

Participants

3

Reactant 2

HCID 71562244(S,E)-tert-butyl 4-(4-(methylsulfonyl)-2-aminobut-3-en-1-yl)benzylcarbamateHCID 86681599(S,E)-tert-butyl (5-(trityl-amino)-7-(methylsulfonyl)hept-6-en-1-yl)carbamate

Product 1

HCID 86681598(S,E)-tert-butyl (5-amino-7-(methylsulfonyl)hept-6-en-1-yl)carbamate

Procedure

This compound was prepared from trityl protected amine 73 in a synthetic procedure similar to that for compound 18. The purity was checked by LC-MS analysis and the amine was subjected to the next step without further purification.

Workup

  1. customThis compound was prepared from trityl
  2. customthe amine was subjected to the next step without further purification

Sources & evidence

ORD record
ord-f5fe96721dad4745ad55a31604d810b3
Source dataset
uspto-grants-2013_12
Patent number
US08609610B2

Reaction notes

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