HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → HCID 131730606, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | (+)-L-Leucine methyl ester | HCID 65105 | — |
| Reactant | tert-butyl N-[(2S)-4-methyl-1-oxopentan-2-yl]carbamate | HCID 104275 | — |
| Reactant | O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate | HCID 42624899 | — |
| Reactant | HCID 131730607 | HCID 131730607 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 131730606 | HCID 131730606 | — |
Reaction Steps
This compound was synthesized via general Boc-based peptide coupling procedures using HCTU from H-Leu-OMe, Boc-Leu-H and N3-Phe-H. The last step involved the introduction of the hydrazide by stirring of a mixture containing tripeptide N3-Phe-Leu-Leu-OMe (1.51 g, 3.49 mmol) and hydrazine monohydrate (30 eq., 105 mmol, 5.1 mL) in NeOH (30 mL) for 15 hours at room temperature. The title compound was obtained after coevaporation of the mixture with toluene (3×) as a colorless solid (yield: 1.51 g, 3.49 mmol, quant.). LC-MS: Rt (min): 6.87 (ESI-MS (m/z): 432.13 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609610B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-f48d3cfa989041c8ab33e1b63a700ee7 |
| Source note | uspto-grants-2013_12 |