反应详情

To a solution of 7-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[4.5]decane-1-carboxylic acid tert-butyl ester (60 mg) in chloroform (1.0 ml) were added 4M hydrochloric acid-ethyl acetate (1.5 ml) and 2M hydrochloric acid-methanol (0.5 ml), and the mixture was stirred at room temperature for 2.5 hours. The reaction mixture was concentrated under reduced pressure, and then azeotroped with toluene. The residue was neutralized by the addition of 4M aqueous sodium hydroxide solution, and thereto was added saturated aqueous sodium chloride solution. The mixture was extracted with chloroform. The separated organic solvent was concentrated under reduced pressure to give the titled compound (30 mg).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customazeotroped with toluene
3. additionThe residue was neutralized by the addition of 4M aqueous sodium hydroxide solution
4. additionwas added saturated aqueous sodium chloride solution
5. extractionThe mixture was extracted with chloroform
6. concentrationThe separated organic solvent was concentrated under reduced pressure