Triethylamine → HCID 46869634, compound

Participants

Reaction Steps

A mixture of Example 9 (130 mg; 0.34 mmol), 1-(methylsulfonyl)piperazine (276 mg; 1.68 mmol) and N,N-diethylethanamine (170 mg; 1.68 mmol) in THF (3 mL) and water (3 mL) was stirred at 115° C. for 48 hours then concentrated in vacuo. The residue was taken up in EA, washed with aq. citric acid, dried over magnesium sulfate and concentrated in vacuo. Purification by column chromatography (EA/EtOH/AcOH, 90/10/1) afforded the title compound as an orange solid.

Provenance & Evidence