HCID 46869088, compound → HCID 46869635, compound

Participants

Reaction Steps

A mixture of Example 9 (30 mg; 0.08 mmol), Pd(PPh3)4 (4.5 mg) and 2M methylzinc chloride (0.16 mL, 0.31 mmol) in THF (5 mL) was stirred at 80° C. for 16 hours then concentrated in vacuo. The residue was partitioned between EA and aq. citric acid and the two phases separated. The aqueous layer was dried over magnesium sulfate and concentrated in vacuo. Purification by column chromatography (EA/EtOH/AcOH, 90/10/1) afforded the title compound as a yellow solid.

Provenance & Evidence