Cesium carbonate → HCID 46869636, compound

Participants

Reaction Steps

A mixture of Example 9 (145 mg; 0.37 mmol), 1-naphthylboronic acid (142 mg; 0.82 mmol), cesium carbonate (489 mg; 1.50 mmol) and Pd(PPh3)4 (87 mg; 0.07 mmol) in DMF (4 mL) was stirred at 150° C. for one hour (microwave heating) then concentrated in vacuo. The residue was partitioned between EA and aq. citric acid and the two phases separated. The aqueous layer was dried over magnesium sulfate and concentrated in vacuo. Precipitation from EA/Et2O afforded the title compound as a yellow solid.

Provenance & Evidence