Sodium Hydroxide → HCID 57936043, compound

Participants

Reaction Steps

To a solution of ethyl 2-(3-(4-chlorophenylamino)-3-methylbutanamido)acetate (1.34 g, 4.49 mmol) in THF (20 mL), was added aq. sodium hydroxide (10 mL, 4.49 mmol). The mixture was stirred at rt overnight. The reaction was quenched with 1N HCl, extracted into EtOAc, and the combined organic extracts were dried over Na2SO4 and concentrated to give 2-(3-(4-chlorophenylamino)-3-methylbutanamido)acetic acid (1.2 g, 99% yield) as a yellow solid.

Provenance & Evidence