6-Amino-1-ethyl-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione → 5,6-diamino-1-ethyl-3-propylpyrimidine-2,4(1H,3H)-dione

Participants

Reaction Steps

To a solution of 6-amino-1-ethyl-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione (300 mg) in methanol (10 ml) was added 10% palladium on carbon catalyst (50 mg), and the mixture was hydrogenated under hydrogen at 30 psi for 2 hours. The mixture was filtered through celite, and solvent was removed from the filtrate under reduced pressure, to provide 5,6-diamino-1-ethyl-3-propyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (2).

Provenance & Evidence