3-amino-2-(trifluoromethyl)-4(3H)-quinazolinone → 2-[(1S,2S,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-N-[4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl]acetamide

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Reaction Steps

The product from Example 1C and 3-amino-2-(trifluoromethyl)quinazolin-4(3H)-one (Bionet) were processed using method analogous to that described in Example 1D to afford the title compound. 1H NMR (300 MHz, CDCl3) δ ppm 1.00 (d, J=9.8 Hz, 1H) 1.08 (s, 3H) 1.23 (d, J=5.1 Hz, 3H) 1.85-2.05 (m, 5H) 2.06-2.24 (m, 1H) 2.31-2.45 (m, 2H) 2.53-2.61 (m, 2H) 2.62-2.76 (m, 1H) 7.58 (s, 1H) 7.60-7.68 (m, 1H) 7.88 (d, J=3.7 Hz, 1H) 8.31 (d, J=7.8 Hz, 1H); MS (ESI+) m/z 394 (M+H)+.

Provenance & Evidence