Hydrochloric Acid → HCID 68749089, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ((1S,2R,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)methanethiol (Eisen, Moris; et al. Inorg. Chim. Acta 1991, 188, 167-176) (52.0 g, 0.30 mmol) and potassium hydroxide (41.2 g, 0.62 mmol) in water (200 mL) was added α-chloro-propionic acid (33.2 g, 0.306 mmol) drop wise. The mixture was heated at 100° C. for 1 hour. The mixture was cooled and acidified to pH=1 with 6N HCl (100 mL). The product was extracted with ether, dried with magnesium sulfate and concentrated. The residue was distilled at reduced pressure (143-147° C., 0.5 mm of Hg) to obtain the title compound.

Provenance & Evidence