Sodium borohydride → HCID 68755830, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled solution of Example 23A (0.62 g, 2.8 mmol) in EtOH (20 mL) was added sodium borohydride (0.13 g, 3.3 mmol) in portions at 0° C. The mixture was stirred at 0° C. for 4 hours and at room temperature overnight. The reaction mixture was then cooled, quenched with 1M NaHCO3, extracted with dichloromethane (3×15 mL). The combined organic layers were dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography (SiO2, 0-30% of ethyl acetate in hexanes) to obtain 0.35 g of the title compound. MS (DCI/NH3) m/z 244 (M+NH4)+

Provenance & Evidence