1-(Bromomethyl)-2-chloro-4-fluorobenzene → 2-(tert-butoxy)-2-(1-(2-chloro-4-fluorobenzyl)-4-(chroman-6-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

関与物質

反応手順

The title compound was prepared in a manner similar to that described in Example 27, Step H from methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate and 1-(bromomethyl)-2-chloro-4-fluorobenzene. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.50-7.43 (m, 1 H), 7.25-7.15 (m, 2 H), 7.13-7.06 (m, 2 H), 6.97-6.88 (m, 2 H), 6.29 (dd, J=3.5, 11.7 Hz, 1 H), 5.70-5.63 (m, 1 H), 5.61-5.51 (m, 2 H), 4.32-4.26 (m, 2 H), 2.96-2.80 (m, 2 H), 2.74 (s, 3 H), 2.16-2.04 (m, 2 H), 1.02-0.91 (s, 9H); LC/MS (m/z) ES+=537.33 (M+1).

情報源と証拠