3,4,5-Trifluorobenzyl bromide → 2-Tert-butoxy-2-[4-chroman-6-yl-6-methyl-1-[(3,4,5-trifluorophenyl)methyl]pyrrolo[2,3-b]pyridin-5-yl]acetic acid

Participants

Reaction Steps

The title compound was prepared in a manner similar to that described in Example 27, Step H from methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate and 3,4,5-trifluorobenzyl bromide. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.50-7.43 (m, 1 H), 7.24-7.17 (m, 1 H), 7.07 (t, J=3.0 Hz, 1 H), 6.97-6.87 (m, 3 H), 6.35 (dd, J=3.3, 11.3 Hz, 1 H), 5.60-5.42 (m, 3 H), 4.29 (t, J=4.8 Hz, 2 H), 2.92-2.80 (m, 2 H), 2.76 (s, 3 H), 2.15-2.07 (m, 2 H), 1.01-0.91 (s, 9 H); LC/MS (m/z) ES+=539.34 (M+1).

Provenance & Evidence