3-Fluoro-4-methylbenzyl bromide → 2-Tert-butoxy-2-[4-chroman-6-yl-1-[(3-fluoro-4-methyl-phenyl)methyl]-6-methyl-pyrrolo[2,3-b]pyridin-5-yl]acetic acid

Participants

Reaction Steps

The title compound was prepared in a manner similar to that described in Example 27, Step H from methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate and 3-fluoro-4-methylbenzyl bromide. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.50-7.42 (m, 1 H), 7.21 (dd, J=1.9, 10.8 Hz, 1 H), 7.14 (t, J=7.7 Hz, 1 H), 7.05 (t, J=3.4 Hz, 1 H), 6.99-6.89 (m, 3 H), 6.28 (dd, J=3.5, 11.5 Hz, 1 H), 5.60-5.56 (m, 1 H), 5.56-5.39 (m, 2 H), 4.28 (t, J=4.5 Hz, 2 H), 2.95-2.80 (m, 2 H), 2.76 (s, 3 H), 2.25 (s, 3 H), 2.09 (d, 2 H), 1.03-0.88 (s, 9 H); LC/MS (m/z) ES+=517.38 (M+1).

Provenance & Evidence