1-(Bromomethyl)-3-chloro-2-fluorobenzene → HCID 71209381, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to that described in Example 27, Step H from methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate and 3-chloro-2-fluorobenzyl bromide. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.49-7.42 (m, 1 H), 7.38-7.31 (m, 1 H), 7.24-7.11 (m, 3 H), 7.06-7.00 (m, 1 H), 6.94 (dd, J=4.5, 8.4 Hz, 1 H), 6.30 (dd, J=3.5, 11.5 Hz, 1 H), 5.71-5.52 (m, 3H), 4.33-4.26 (m, 2 H), 2.95-2.81 (m, 2 H), 2.76 (s, 3 H), 2.14-2.03 (m, 2 H), 1.01-0.91 (s, 9 H); LC/MS (m/z) ES+=537.4 (M+1).

Provenance & Evidence