1-(Bromomethyl)-2-chloro-4-fluorobenzene → HCID 71209186, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared in a manner similar to that described in Example 1, Step H from (S)-methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate and 1-(bromomethyl)-2-chloro-4-fluorobenzene, but purified on a ChiralPak ADH column (250×30 mm i.d., 5 um; ChiralTechnologies, West Chester, Pa.) under supercritical conditions maintained at 40° C., 140 bar, with MeOH modified CO2 (25% Isopropanol, 75% CO2) delivered at a combined flow rate of 90 g/min on a PIC Preplab 200 SFC system (Avignon, France). Triggered collections were made using a Knauer selectable wavelength UV-Vis detector at 230 nm (Rt=5.52 minutes): 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.50-7.42 (m, 1 H), 7.25-7.16 (m, 2 H), 7.14-7.05 (m, 2 H), 6.97-6.88 (m, 2 H), 6.30 (dd, J=3.5, 11.7 Hz, 1 H), 5.71-5.63 (m, 1 H), 5.61-5.52 (m, 2 H), 4.32-4.26 (m, 2 H), 2.96-2.79 (m, 2 H), 2.76 (s, 3 H), 2.08 (dd, J=5.0, 9.5 Hz, 2 H), 1.03-0.90 (s, 9 H); LC/MS (m/z) ES+=537.30 (M+1).

Provenance & Evidence