2-Fluoro-4-(trifluoromethyl)benzyl bromide → HCID 71209410, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to that described in Example 27, Step H from methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate and 2-fluoro-4-(trifluoromethyl)benzyl bromide. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.49-7.41 (m, 1 H), 7.39-7.28 (m, 3 H), 7.25-7.18 (m, 1 H), 7.14-7.10 (m, 1 H), 6.93 (dd, J=3.9, 8.4 Hz, 1 H), 6.29 (dd, J=3.5, 12.1 Hz, 1 H), 5.70-5.62 (m, 1 H), 5.62-5.52 (m, 2 H), 4.33-4.25 (m, 2 H), 2.96-2.77 (m, 2 H), 2.73 (s, 3 H), 2.16-2.03 (m, 2 H), 1.01-0.92 (s, 9 H); LC/MS (m/z) ES+=571 (M+1).

Provenance & Evidence