1-(Bromomethyl)-3-(trifluoromethoxy)benzene → HCID 71209366, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to that described in Example 27, Step H from methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate and 3-(trifluoromethoxy)benzyl bromide. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.52-7.42 (m, 1 H), 7.35 (t, J=8.2 Hz, 1 H), 7.26-7.12 (m, 4 H), 7.06 (t, J=3.2 Hz, 1 H), 6.97-6.91 (m, 1 H), 6.30 (dd, J=3.5, 11.3 Hz, 1 H), 5.63-5.46 (m, 3 H), 4.33-4.25 (m, 2 H), 2.97-2.79 (m, 2 H), 2.78-2.70 (m, 3 H), 2.15-2.03 (m, 2 H), 1.03-0.88 (s, 9 H); LC/MS (m/z) ES+=569.35 (M+1).

Provenance & Evidence