1-(Bromomethyl)-4-(trifluoromethyl)benzene → 2-Tert-butoxy-2-[6-methyl-4-(p-tolyl)-1-[[4-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridin-5-yl]acetic acid

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Reaction Steps

The title compound was prepared from methyl 2-(tert-butoxy)-2-(6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate and 1-(bromomethyl)-4-(trifluoromethyl)benzene in a manner similar to that described in Example 25 as a yellow solid. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm=7.69-7.63 (m, 1 H), 7.60 (d, J=8.0 Hz, 2 H), 7.44-7.32 (m, 5 H), 7.06 (d, J=3.5 Hz, 1 H), 6.28 (d, J=3.5 Hz, 1 H), 5.71-5.51 (m, 3 H), 2.76 (s, 3 H), 2.48 (s, 3 H), 0.96 (s, 9 H); LCMS (m/z) ES+=511 (M+1).

Provenance & Evidence