1-(Bromomethyl)-4-(trifluoromethoxy)benzene → HCID 71209440, compound

Participants

Reaction Steps

The title compound was prepared in a manner similar to that described in Example 27, Step H from methyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate and 4-(trifluoromethoxy)benzyl bromide. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.51-7.43 (m, 1 H), 7.33-7.28 (m, 2 H), 7.26-7.15 (m, 3 H), 7.06 (t, J=3.3 Hz, 1 H), 6.94 (dd, J=5.3, 8.4 Hz, 1 H), 6.29 (dd, J=3.5, 11.7 Hz, 1 H), 5.65-5.55 (m, 2 H), 5.53-5.43 (m, 1 H), 4.32-4.26 (m, 2 H), 2.95-2.81 (m, 2 H), 2.78-2.73 (m, 3 H), 2.14-2.05 (m, 2 H), 0.97 (s, 9 H); LC/MS (m/z) ES+=569.19 (M+1).

Provenance & Evidence