4-Fluoro-3-(trifluoromethyl)benzyl bromide → HCID 71209357, compound

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The title compound was prepared from methyl 2-(tert-butoxy)-2-(6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate and 4-(bromomethyl)-1-fluoro-2-(trifluoromethyl)benzene in a manner similar to that described in Example 25 as a yellow solid. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm=7.67-7.58 (m, 2 H), 7.48-7.38 (m, 2 H), 7.34 (d, J=7.8 Hz, 2 H), 7.16 (t, J=9.3 Hz, 1 H), 7.05 (d, J=3.5 Hz, 1 H), 6.26 (d, J=3.5 Hz, 1H), 5.60-5.45 (m, 3 H), 2.75 (s, 3 H), 2.47 (s, 3 H), 0.95 (s, 9 H); LCMS (m/z) ES+=529 (M+1).

Provenance & Evidence