Azobisisobutyronitrile → 2-(Bromomethyl)-4-nitrobenzonitrile

Participants

Reaction Steps

A degassed solution of 2-methyl-4-nitrobenzonitrile (10 g, 61.7 mmol), N-bromosuccinimide (13.2 g (74.17 mmol, 1.2 eq.) and azobisisobutyronitrile (AlBN) (2.0 g, 12.18 mmol, 0.2 eq) in 300 ml CCl4 was heated at reflux for 3 days. After solvent was evaporated the residue was taken in ethyl acetate and washed 2× with aq. NaHCO3, aq. Na2S2O3, brine, dried over MgSO4, filtered, concentrated and purified chromatography using 15% ethyl acetate in hexane to provide 11.7 g of 2-bromomethyl-4-nitrobenzonitrile.

Provenance & Evidence