反应详情

The compound from step 4 (0.3 g, 0.96 mmol) was dissolved in DMF (4.83 ml), 4-cyano-3-fluoroaniline (0.131 g, 1 eq) and NaH (0.155 g of 60% dispersion in mineral oil, 4 eq) were added. After 1 hour LCMS showed complete conversion, the reaction was quenched with NH4Cl(sat) and extracted with EtOAc. The extracts were dried concentrated and the residue purified by silica gel chromatography (0-20% EtOAc in hexane) to give 0.3 g of the title compound.

1. customconversion, the reaction was quenched with NH4Cl(sat)
2. extractionextracted with EtOAc
3. customThe extracts were dried
4. concentrationconcentrated
5. customthe residue purified by silica gel chromatography (0-20% EtOAc in hexane)