反应详情

The compound from step 5 (0.3 g, 0.73 mmol) was dissolved in (3:1) MeOH/THF (7.3 ml), 10% Palladium on carbon (30 mg) was added and the mixture placed under H2 (1 atm). After 1 hour LCMS showed that the reaction was complete, the catalyst was removed by filtration and the mixture concentrated to give 200 mg of the title compound. LCMS=321.2 (MH+)

1. customthe catalyst was removed by filtration
2. concentrationthe mixture concentrated