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HRID1912654

反应详情

EQUATION

反应方程式

HRID 1912654 的结构方程式

REACTANTS

反应物

2
结构：Cl.Cl.NCCON
HCID14362326

2-(Aminooxy)ethan-1-amine--hydrogen chloride (1/2)

C2H10Cl2N2O

结构：COC[C@H]1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)CCC(=O)CC12
HCID69010272

未命名化合物

PRODUCTS

生成物

1
结构：COC[C@H]1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)CCC(=NOCCN)CC12.Cl
HCID86651473

未命名化合物

收率 33%

PROCEDURE

实验过程

Prepared in 33% yield as described in Example 1 starting from 6α-methoxymethylandrostane-3,17-dione (II-ap, Prepn. 16) and 2-aminoethoxyamine dihydrochloride. The crude product was crystallized from Et2O/EtOAc. 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 7.82 (bb, 3H), 4.06 (m, 2H), 3.22 (m, 2H), 3.20 (s, 3H), 3.05 (m, 1H), 3.02 (m, 2H), 2.45-0.60 (m, 20H), 0.89 (s, 3H), 0.78 (s, 3H).

WORKUP

后处理

  1. customPrepared in 33% yield
  2. customThe crude product was crystallized from Et2O/EtOAc