HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-aminopropoxyamine dihydrochloride → HCID 178462164, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-aminopropoxyamine dihydrochloride | HCID 86651486 | — |
| Reactant | (6E,8R,9S,10R,13S,14S)-6-hydroxyimino-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-dione | HCID 87653583 | — |
| Product | HCID 178462164 | HCID 178462164 | 93% |
Reaction Steps
Prepared as described in Example 1 starting from 6-(E)-hydroxyiminoandrostane-3,17-dione (II-at, Prepn. 20, 500 mg) and (S)-2-aminopropoxyamine dihydrochloride (Prepn. 92, 257 mg). The crude product was crystallized from MeOH/EtOAc to give the title compound as a white solid (503 mg, 75%). NMR (300 MHz, DMSO-d6, ppm from TMS): δ 10.50 (1H, s), 7.98 (3H, m), 3.97 (2H, m), 3.40 (1H, m), 3.11 (0.5H, m), 3.05 (0.5H, m), 2.54-1.15 (22H, m), 0.79 (3H, s), 0.78 (3H, s)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609644B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-1219242e5d90445e892a8e99a72171a0 |
| Source note | uspto-grants-2013_12 |