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HRID1912659

反应详情

EQUATION

反应方程式

HRID 1912659 的结构方程式

REACTANTS

反应物

2
结构：C[C@@H](N)CON.Cl.Cl
HCID86651490

未命名化合物

结构：C[C@]12CCC(=O)CC1/C(=N/O)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
HCID87653583

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](N)CON=C1CC[C@@]2(C)C(CC[C@H]3[C@@H]4CCC[C@@]4(C)CC[C@@H]32)C1.C[C@]12CCCCC1/C(=N/O)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12.Cl
HCID178462163

未命名化合物

收率 93%

PROCEDURE

实验过程

Prepared as described in Example 1 starting from 6-(E)-hydroxyiminoandrostane-3,17-dione (II-at, Prepn. 20, 500 mg) and (R)-2-aminopropoxyamine dihydrochloride (Prepn. 93, 257 mg). The crude product was crystallized from MeOH/EtOAc to give the title compound as a white solid (503 mg, 75%). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 10.50 (1H, s), 7.98 (3H, m), 3.97 (2H, m), 3.40 (1H, m), 3.11 (0.5H, m), 3.05 (0.5H, m), 2.54-1.15 (22H, m), 0.79 (3H, s), 0.78 (3H, s).

WORKUP

后处理

  1. customPrepared
  2. customThe crude product was crystallized from MeOH/EtOAc