HRID1912667

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@]12CC[C@H]3[C@@H](C[C@@H]4O[C@@]45C[C@@H](O)CC[C@]35C)[C@@H]1CCC2=O

HCID7075155

未命名化合物

结构：C[C@]12CCCCC1=CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC13OCCOC12OCCO3

HCID86651495

未命名化合物

PRODUCTS

生成物

结构：C[C@]12CC[C@H]3[C@@H](C[C@@H]4O[C@@]45CCCC[C@]35C)[C@@H]1CC13OCCOC12OCCO3

HCID86651494

未命名化合物

收率 45%

PROCEDURE

实验过程

17,17-Bis(ethylendioxy)-5α,6α-epoxyandrostane was prepared in 45% yield from 3,3:17,17-bis(ethylendioxy)-5-androstene by the procedure described above for the preparation of 3β-hydroxy-5α,6α-epoxyandrostan-17-one (Prepn. 4). The crude product was purified by flash chromatography (SiO2, n-hexane/EtOAc 80/20). 1H-NMR (300 MHz, acetone-d6, ppm from TMS): δ 3.92-3.75 (m, 8H), 2.68 (m, 1H), 2.56 (d, 1H), 1.99-1.06 (m, 18H), 1.09 (s, 3H), 0.78 (s, 3H).

WORKUP

后处理

customThe crude product was purified by flash chromatography (SiO2, n-hexane/EtOAc 80/20)