HRID1912668

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@]12CCC(=O)CC1[C@@H](C#N)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12

HCID69133284

未命名化合物

结构：C[C@]12CC[C@H]3[C@@H](C[C@@H](C#N)[C@@]4(O)CCCC[C@]34C)[C@@H]1CC13OCCOC12OCCO3

HCID86651496

未命名化合物

PRODUCTS

生成物

结构：C[C@]12CC[C@H]3[C@@H](C[C@@H](C#N)[C@@]4(O)CC(=O)CC[C@]34C)[C@@H]1CCC2=O

HCID69811102

未命名化合物

收率 82%

PROCEDURE

实验过程

The title compound II-ai was prepared in 82% yield from 3,3:17,17-bis(ethylendioxy)-5α-hydroxy-6β-cyanoandrostane by the procedure described above for the preparation of 6α-cyanoandrostane-3,17-dione (II-ac, Prepn. 3). The crude product was purified by flash chromatography (SiO2, n-hexane/CH2Cl2/acetone 60/20/20) to give the title compound II-ae. 1H-NMR (300 MHz, acetone-d6, ppm from TMS): δ 4.27 (s, 1H), 3.21 (d, 1H), 2.92 (m, 1H), 2.62-1.24 (m, 18H), 1.50 (s, 3H), 0.93 (s, 3H).

WORKUP

后处理

customThe crude product was purified by flash chromatography (SiO2, n-hexane/CH2Cl2/acetone 60/20/20)
customto give the title compound II-ae