HuagongsheHuagongshe Chemistry Print Report · For research reference only
17,17-Bis(ethylendioxy)-6alpha-vinylandrostane → 17,17-Bis(ethylendioxy)-6alpha-(2-hydroxyethyl)androstane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 17,17-Bis(ethylendioxy)-6alpha-vinylandrostane | HCID 86635574 | — |
| Reactant | 17,17-Bis(ethylendioxy)-6beta-hydroxymethylandrostane | HCID 86651497 | — |
| Product | 17,17-Bis(ethylendioxy)-6alpha-(2-hydroxyethyl)androstane | HCID 86635575 | 96% |
Reaction Steps
17,17-Bis(ethylendioxy)-6α-(2-hydroxyethyl)androstane was prepared in 96% yield from 3,3:17,17-bis(ethylendioxy)-6α-vinylandrostane (Prepn. 11) by the procedure described above for the preparation of 3,3:17,17-bis(ethylendioxy)-6β-hydroxymethylandrostane (Prepn. 9). The crude was purified by flash chromatography (SiO2, n-hexane/acetone 80/20). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 4.25 (t, 1H), 3.86-3.70 (m, 8H), 3.35 (m, 2H), 1.91-0.42 (m, 23H), 0.75 (s, 3H), 0.74 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609644B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-57e43c28166243ca8288574c007a3b19 |
| Source note | uspto-grants-2013_12 |