HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-ethylhydroxylamine hydrochloride → (E,2S,5S,6R,14R,15S)-N-ethoxy-2,6-dimethyl-18,21,22,25-tetraoxahexacyclo[15.4.4.01,17.02,15.05,14.06,11]pentacosan-12-imine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-ethylhydroxylamine hydrochloride | HCID 76850 | — |
| Reactant | 17,17-Bis(ethylendioxy)androstan-6-one | HCID 67535914 | — |
| Product | (E,2S,5S,6R,14R,15S)-N-ethoxy-2,6-dimethyl-18,21,22,25-tetraoxahexacyclo[15.4.4.01,17.02,15.05,14.06,11]pentacosan-12-imine | HCID 178474300 | 90% |
Reaction Steps
17,17-Bis(ethylendioxy)-6(E)-ethoxyiminoandrostane was prepared in 90% yield starting from 3,3:17,17-bis(ethylendioxy)androstan-6-one and NH2OCH2CH3.HCl by the procedure described above in Prepn. 21. 1H-NMR (300 MHz, acetone-d6, ppm from TMS): δ 3.99 (2H, q), 3.92-3.75 (8H, m), 3.25 (1H, dd), 2.25 (1H, m), 1.99-0.94 (18H, m), 1.17 (3H, t), 0.82 (3H, s), 0.75 (3H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08609644B2 |
| Source dataset | uspto-grants-2013_12 |
| ORD ID | ord-663986fcd0a34e7a874ab5a074042171 |
| Source note | uspto-grants-2013_12 |