HCID 69133284, compound → HCID 69133427, compound

Participants

Reaction Steps

The title compound II-bh was prepared in 60% yield from 3,3:17,17-bis(ethylendioxy)-6-(E)-(2-hydroxyethylidene)androstane by the procedure described above for the preparation of 6α-cyanoandrostane-3,17-dione (II-ac, Prepn. 3). The combined organic extracts were washed with H2O, dried over Na2SO4 and evaporated to dryness. The residue was purified by flash chromatography (SiO2, n-hexane/acetone 70/30). 1H-NMR (300 MHz, acetone-d6, ppm from TMS: δ 5.14 (m, 1H), 4.17 (m, 2H), 3.53 (t, 1H), 2.84 (dd, 1H), 2.65-1.01 (m, 20H), 0.97 (s, 3H), 0.85 (s, 3H).

Provenance & Evidence