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HRID1912718

反应详情

EQUATION

反应方程式

HRID 1912718 的结构方程式

REACTANTS

反应物

3
结构：C=C1CC2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC45OCCOC43OCCO5)[C@H]12
HCID86635586

未命名化合物

结构：C[C@]12CCCCC1C[C@H](CO)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC13OCCOC12OCCO3
HCID86635587

未命名化合物

结构：C[C@]12CCCCC1[C@H](CO)C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC13OCCOC12OCCO3
HCID86651497

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CCCCC1C[C@@H](CO)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC13OCCOC12OCCO3
HCID86635588

未命名化合物

收率 70%

PROCEDURE

实验过程

17,17-Bis(ethylendioxy)-7β-hydroxymethylandrostane and 3,3:17,17-bis(ethylendioxy)-7α-hydroxymethylandrostane were prepared in 10% and 70% yield, respectively, from 3,3:17,17-bis(ethylendioxy)-7-methyleneandrostane (Prepn. 48) by the procedure described above for the preparation of 3,3:17,17-bis(ethylendioxy)-6β-hydroxymethylandrostane (Prepn. 9). The residue was purified by flash chromatography (SiO2, n-hexane/EtOAc 60/40). 3,3:17,17-Bis(ethylendioxy)-7β-hydroxymethylandrostane: 1H-NMR (300 MHz, acetone-d6, ppm from TMS): δ 3.84 (m, 8H), 3.58 (m, 2H), 3.32 (t, 1H), 1.94-0.68 (m, 21H), 0.85 (s, 3H), 0.81 (s, 3H). 3,3:17,17-Bis(ethylendioxy)-7α-hydroxymethylandrostane: 1H-NMR (300 MHz, acetone-d6, ppm from TMS): δ 3.83 (m, 8H), 3.67 (m, 2H), 3.34 (t, 1H), 1.97-0.91 (m, 21H), 0.87 (s, 3H), 0.81 (s, 3H).

WORKUP

后处理

  1. customThe residue was purified by flash chromatography (SiO2, n-hexane/EtOAc 60/40)