huagongshe.com
HRID1912740

反应详情

EQUATION

反应方程式

HRID 1912740 的结构方程式

REACTANTS

反应物

1
结构：C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)CC[C@@H](SC(C)=O)CC12
HCID86635598

未命名化合物

PRODUCTS

生成物

1
结构：C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)CC[C@@H](S)CC12
HCID86635599

未命名化合物

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：[Na+].[OH-]
溶剂HCID14798

Sodium Hydroxide

HNaO

PROCEDURE

实验过程

To a solution of 3α-acetylthio-6-methyleneandrostane-17-one (210 mg) in MeOH (3 mL), 1N NaOH (0.6 mL) was added. After 1 h at room temperature 5% NaH2PO4 aqueous solution was added and the mixture extracted with Et2O (2×20 mL). The combined organic extracts were washed with brine, dried over Na2SO4 and evaporated to dryness to give 3α-mercapto-6-methyleneandrostane-17-one (185 mg, 100%).

WORKUP

后处理

  1. extractionthe mixture extracted with Et2O (2×20 mL)
  2. washThe combined organic extracts were washed with brine
  3. dry with materialdried over Na2SO4
  4. customevaporated to dryness