Hydrochloric Acid → HCID 69134667, compound

Participants

Reaction Steps

To a solution of 3α-formyloxyandrostane-6,17-dione (2.20 g) in MeOH (100 mL), K2CO3 (2.70 g) was added and the mixture stirred at room temperature for 10 minutes, then HCl 1N (20 mL) was added, the phases were separated and the aqueous one extracted with EtOAc (2×). The combined organic extracts were washed with H2O, dried over Na2SO4 and evaporated to dryness to give 3α-hydroxyandrostane-6,17-dione (quantitative yield), which was used in the next step without purification. 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 4.35 (1H, d), 3.40 (1H, m), 2.40-0.95 (20H, m), 0.80 (3H, s), 0.69 (3H, s).

Provenance & Evidence