HCID 23155053, compound → HCID 23155220, compound

HRID 1912754Notes

Reaction equation

HRID 1912754 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:18]3[CH:17]=[CH:16][N:15]=[CH:14][C:13]=3[N:12]=[CH:11]2)=[CH:6][CH:5]=1)([O-])=O.[H][H]>CO.[C].[Pd]>[N:10]1([C:7]2[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[C:18]2[CH:17]=[CH:16][N:15]=[CH:14][C:13]=2[N:12]=[CH:11]1

Participants

5

Reactant 2

HCID 23155053HCID 23155053, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23155220HCID 23155220, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

In 20 mL of methanol, 33 mg (0.1237 mmol) of 1-(4-nitrophenyl)-1H-imidazo[4,5-c]pyridine prepared in Step A was dissolved and the solution was stirred on 5 mg of 10% palladium carbon in a hydrogen atmosphere at room temperature at normal pressures for one hour. After removal of the palladium carbon by filtration, the solvent was distilled under reduced pressure, and the obtained product was vacuum dried to obtain 4-(imidazo[4,5-c]-pyridin-1-yl)aniline as a white solid. This product was used in process C without further purification.

Workup

  1. customAfter removal of the palladium carbon
  2. filtrationby filtration
  3. distillationthe solvent was distilled under reduced pressure
  4. customdried

Sources & evidence

ORD record
ord-995224077a1b424a9c6c9df482385450
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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