1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 23155191, compound

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Reaction Steps

The 4-(imidazo[4,5-c]pyridin-3-yl)aniline prepared in Step A was dissolved in 10 mL of dichloromethane, and 14.2 mg (0.064 mmol) of 4-chloro-3-(trifluoromethyl)phenyl isocyanate was added thereto and the mixture solution was stirred at room temperature for three hours. The solvent was distilled under reduced pressure, and the obtained crude product was recrystallized from ethyl acetate to obtain 20.2 mg (73%) of 1-(4-chloro-3-(trifluoromethyl)-phenyl)-3-(4-imidazo[4,5-c]pyridin-3-ylphenyl)urea (Table 1, Compound No. 2) as a colorless crystal.

Provenance & Evidence