[2-(1-{4-[3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido]phenyl}-1H-indol-4-yloxy)ethyl]-methylcarbamic acid tert-butyl ester → 1-(4-Chloro-3-(tri-fluoromethyl)phenyl)-3-{4-[4-(2-methylamino-ethoxy)-indol-1-yl]phenyl}urea hydrochloride

Participants

Reaction Steps

In 5 ml of a 4N hydrogen chloride ethyl acetate solution, 200 mg (0.33 mmol) of [2-(1-{4-[3-(4-chloro-3-(trifluoromethyl)phenyl)ureido]phenyl}-1H-indol-4-yloxy)ethyl]-methylcarbamic acid tert-butyl ester was dissolved and the solution was stirred at room temperature for 14 hours. The reaction solution was concentrated under reduced pressure, and then the obtained residue was triturated with ethyl acetate to obtain 110 mg (66%) of 1-(4-chloro-3-(tri-fluoromethyl)phenyl)-3-{4-[4-(2-methylamino-ethoxy)-indol-1-yl]phenyl}urea hydrochloride.

Provenance & Evidence