p-Fluoronitrobenzene → HCID 23155225, compound

HRID 1912777Notes

Reaction equation

HRID 1912777 reaction equation
[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([OH:10])[C:4]=2[CH:3]=[CH:2]1.C(OC([N:18]1[CH2:23][CH2:22][N:21]([CH2:24][CH2:25]O)[CH2:20][CH2:19]1)=O)(C)(C)C.F[C:28]1[CH:33]=[CH:32][C:31]([N+:34]([O-])=O)=[CH:30][CH:29]=1.[Cl:37][C:38]1[CH:43]=[CH:42][C:41]([N:44]=[C:45]=[O:46])=[CH:40][C:39]=1[C:47]([F:50])([F:49])[F:48]>>[Cl:37][C:38]1[CH:43]=[CH:42][C:41]([NH:44][C:45]([NH:34][C:31]2[CH:32]=[CH:33][C:28]([N:1]3[C:9]4[C:4](=[C:5]([O:10][CH2:25][CH2:24][N:21]5[CH2:20][CH2:19][NH:18][CH2:23][CH2:22]5)[CH:6]=[CH:7][CH:8]=4)[CH:3]=[CH:2]3)=[CH:29][CH:30]=2)=[O:46])=[CH:40][C:39]=1[C:47]([F:48])([F:49])[F:50]

Participants

5

Reactant 4

HCID 9590p-FluoronitrobenzeneHCID 754211H-indol-4-olHCID 735736Tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylateHCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzene

Product 1

HCID 23155225HCID 23155225, compound

Procedure

The title compound can be synthesized from 1H-indole-4-ol, 4-(2-hydroxyethyl)piperazine-1-carboxylic acid tert-butyl ester, 4-fluoronitrobenzene and 4-chloro-3-(trifluoromethyl)phenyl isocyanate in the same manner as in Example 20 and Example 21.

Sources & evidence

ORD record
ord-c6aa85a260b744e08132bb85971d5126
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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