Acetic Anhydride → HCID 23154959, compound

Participants

Reaction Conditions

Reaction Steps

In 0.2 mL of pyridine, 10.5 mg (0.022 mmol) of 1-{4-[3-(4-chloro-3-(trifluoromethyl)phenyl)ureido]phenyl}-N-hydroxy-1H-indole-5-carboxamidine was dissolved, and 10 mg (0.098 mmol) of acetic anhydride was added thereto, and the mixture solution was stirred at 80° C. for 14 hours. The reaction solution was concentrated under reduced pressure, and then the obtained residue was purified by Megabond Elute Silica Gel (a product of Varian, 1 g, methylene chloride:methanol=20:1) to obtain 4.1 mg (37%) of 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-{4-[5-(5-methyl-[1,2,4]oxadiazol-3-yl)indol-1-yl]phenyl}urea (Table 1, Compound No. 26).

Provenance & Evidence