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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1912781Generated: October 25, 2026

p-Fluoronitrobenzene → 1-[4-(2-Aminopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea hydrochloride

https://huagongshe.com/reaction/1912781

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-FluoronitrobenzeneHCID 9590—
Reactant2-AminopurineHCID 9955—
Reactant1-Chloro-4-isocyanato-2-(trifluoromethyl) benzeneHCID 2733265—
Product1-[4-(2-Aminopurin-9-yl)phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea hydrochlorideHCID 23154933—

Reaction Steps

The title compound can be synthesized from 2-aminopurine, 4-fluoronitrobenzene and 4-chloro-3-(trifluoromethyl)phenyl isocyanate by the same methods as in Examples 29 and 30.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08609656B2
Source datasetuspto-grants-2013_12
ORD IDord-36b385a907b84a55ae6f59d1f118f615
Source noteuspto-grants-2013_12