1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → HCID 23154940, compound

HRID 1912782Notes

Reaction equation

HRID 1912782 reaction equation
C(OC(=O)[N:7]([CH2:26][CH2:27][O:28][CH3:29])[C:8]1[N:16]=[CH:15][N:14]=[C:13]2[C:9]=1[N:10]=[CH:11][N:12]2[C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-])=O)=[CH:19][CH:18]=1)(C)(C)C.[Cl:31][C:32]1[CH:37]=[CH:36][C:35]([N:38]=[C:39]=[O:40])=[CH:34][C:33]=1[C:41]([F:44])([F:43])[F:42]>>[ClH:31].[Cl:31][C:32]1[CH:37]=[CH:36][C:35]([NH:38][C:39]([NH:23][C:20]2[CH:19]=[CH:18][C:17]([N:12]3[CH:11]=[N:10][C:9]4[C:13]3=[N:14][CH:15]=[N:16][C:8]=4[NH:7][CH2:26][CH2:27][O:28][CH3:29])=[CH:22][CH:21]=2)=[O:40])=[CH:34][C:33]=1[C:41]([F:42])([F:43])[F:44]

Participants

3

Reactant 2

HCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzeneHCID 59725882HCID 59725882, compound

Product 1

HCID 23154940HCID 23154940, compound

Procedure

The title compound can be synthesized from (2-methoxyethyl)-[9-(4-nitrophenyl)-9H-purin-6-yl]carbamic acid tert-butyl ester and 4-chloro-3-(trifluoromethyl)phenyl isocyanate by the methods of Steps B and C of Example 1 and Example 30.

Sources & evidence

ORD record
ord-04db505be6154298a5a737d49fde796a
Source dataset
uspto-grants-2013_12
Patent number
US08609656B2

Reaction notes

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