Acetic Anhydride → HCID 23155154, compound

HRID 1912784Notes

Reaction equation

Cl.[NH2:2][C:3]1[CH:32]=[CH:31][C:6]2[N:7]([C:10]3[CH:15]=[CH:14][C:13]([NH:16][C:17]([NH:19][C:20]4[CH:25]=[CH:24][C:23]([Cl:26])=[C:22]([C:27]([F:30])([F:29])[F:28])[CH:21]=4)=[O:18])=[CH:12][CH:11]=3)[CH:8]=[N:9][C:5]=2[CH:4]=1.[C:33](OC(=O)C)(=[O:35])[CH3:34]>>[Cl:26][C:23]1[CH:24]=[CH:25][C:20]([NH:19][C:17](=[O:18])[NH:16][C:13]2[CH:14]=[CH:15][C:10]([N:7]3[C:6]4[CH:31]=[CH:32][C:3]([NH:2][C:33](=[O:35])[CH3:34])=[CH:4][C:5]=4[N:9]=[CH:8]3)=[CH:11][CH:12]=2)=[CH:21][C:22]=1[C:27]([F:29])([F:30])[F:28]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 23155042HCID 23155042, compound

Product 1

HCID 23155154HCID 23155154, compound

Procedure

The title compound can be synthesized from 1-[4-[5-aminobenzimidazol-1-yl]phenyl]-3-(4-chloro-3-(trifluoromethyl)phenyl)urea hydrochloride and acetic anhydride by the same method as in Example 41.

Sources & evidence

ORD record: ord-278488bf6196425b8f748f236d570ad8
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08609656B2

Reaction notes

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